Wortham began painting during her undergraduate years at Macalester College in St. Paul, Minnesota, where she was a student of the late Jerry Rudquist. After completing her bachelor's degree, Wortham worked as a graphic designer, but continued to paint—often, with her children and their friends as subjects. In 2010, she entered the Painting and Drawing MFA program at the University of Wisconsin-Madison, studying under T. L. Solien. Upon graduating in 2013, Wortham moved to Lowertown Lofts Artist Cooperative in St. Paul, MN.

While living in the Twin Cities she participated in the St. Paul Art Crawl for a number of years, winning both the poster contest and media contest in 2017. She also served as the painting and drawing judge for the Minnesota State Fair art exhibition.

Wortham now paints out of her woodland studio in Clam Falls, Wisconsin. Her work has been shown at the Catherine C. Murphy Gallery at St. Catherine University, the Duluth Art Institute, Woman Made Gallery in Chicago, Keep Contemporary Gallery in Santa Fe, and Saatchi's Other Art Fair in Chicago. She has received regional and national recognition from organizations such as the Minnesota State Arts Board, Minneapolis Star Tribune, and the North American Graduate Art Survey, and the White Bear Lake Arts Board.